NFATC1 monoclonal antibody, clone AT1C3
产品名称： NFATC1 monoclonal antibody, clone AT1C3
英文名称： NFATC1 monoclonal antibody, clone AT1C3
产品编号： MAB3209
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against partial recombinant NFATC1.
- Immunogen:
- Recombinant protein corresponding to amino acids 428-716 of human NFATC1.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Isotype:
- IgG2a, kappa
- Storage Buffer:
- In PBS, pH 7.4 (0.1% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling.
Akimzhanov A, Krenacs L, Schlegel T, Klein-Hessling S, Bagdi E, Stelkovics E, Kondo E, Chuvpilo S, Wilke P, Avots A, Gattenlohner S, Muller-Hermelink HK, Palmetshofer A, Serfling E.Am J Pathol. 2008 Jan;172(1):215-24. Epub 2007 Dec 21.
- 2.
- Autoamplification of NFATc1 expression determines its essential role in bone homeostasis.
Asagiri M, Sato K, Usami T, Ochi S, Nishina H, Yoshida H, Morita I, Wagner EF, Mak TW, Serfling E, Takayanagi H.J Exp Med. 2005 Nov 7;202(9):1261-9.
- 3.
- Transcription factors of the NFAT family: regulation and function.
Rao A, Luo C, Hogan PG.Annu Rev Immunol. 1997;15:707-47.
- Applications
- Western Blot (Cell lysate)
- Cell lysates of Ramos (20 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with NFATC1 monoclonal antibody, clone AT1C3 (Cat # MAB3209 ; 1 : 1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
- Entrez GeneID:
- 4772
- Protein Accession#:
- NP_765978
- Gene Name:
- NFATC1
- Gene Alias:
- MGC138448,NF-ATC,NFAT2,NFATc
- Gene Description:
- nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
- Omim ID:
- 600489
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq
- Other Designations:
- NFAT transcription complex cytosolic component,nuclear factor of activated T-cells, cytosolic component 1