CHEK2 purified MaxPab mouse polyclonal antibody (B01P)-抗体-抗体-生物在线
亚诺法生技股份有限公司（Abnova)
CHEK2 purified MaxPab mouse polyclonal antibody (B01P)

CHEK2 purified MaxPab mouse polyclonal antibody (B01P)

商家询价

产品名称： CHEK2 purified MaxPab mouse polyclonal antibody (B01P)

英文名称： CHEK2 purified MaxPab mouse polyclonal antibody (B01P)

产品编号： H00011200-B01P

产品价格： null

产品产地： 台湾

品牌商标： Abnova

更新时间： null

使用范围：

亚诺法生技股份有限公司（Abnova)
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  • 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
  • 邮编 : 11493
  • 所在区域 : 台湾
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  • 邮箱 : sales@abnova.com.tw
进入展台

  • Specification
  • Product Description:
  • Mouse polyclonal antibody raised against a full-length human CHEK2 protein.
  • Immunogen:
  • CHEK2 (NP_009125.1, 1 a.a. ~ 543 a.a) full-length human protein.
  • Sequence:
  • MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Storage Buffer:
  • In 1x PBS, pH 7.2
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Quality Control Testing:
  • Antibody reactive against mammalian transfected lysate.
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • CHEK2 MaxPab polyclonal antibody. Western Blot analysis of CHEK2 expression in human liver.
  • Protocol Download
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western Blot analysis of CHEK2 expression in transfected 293T cell line (H00011200-T01) by CHEK2 MaxPab polyclonal antibody.

    Lane 1: CHEK2 transfected lysate(59.73 KDa).
    Lane 2: Non-transfected lysate.
  • Protocol Download
  • Detection Antibody
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Detection Antibody
  • Gene Information
  • Gene Name:
  • CHEK2
  • Gene Alias:
  • CDS1,CHK2,HuCds1,LFS2,PP1425,RAD53
  • Gene Description:
  • CHK2 checkpoint homolog (S. pombe)
  • Gene Summary:
  • In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000028871,checkpoint-like protein CHK2,protein kinase CHK2,serine/threonine-protein kinase CHK2

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