Anti-CHRNA7 Polyclonal Antibody

品牌：solarbio | 货号：K002857P

商品货号：	商品品牌：	规格	基本售价：	选择规格
K002857P-50ul	solarbio	50ul	960.00元
K002857P-100ul	solarbio	100ul	1600.00元

英文名称	Anti-CHRNA7 Polyclonal Antibody
别名	CHRNA7-2;NACHRA7
应用	WB IHC
稀释比例	WB 1:500-2000. IHC 1:50-200.
交叉反应	Human Mouse Rat
蛋白分子量	56kDa
Gene ID	1139
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant protein of human CHRNA7
性状	液体
Public Immunogen Range	Recombinant protein of human CHRNA7
Subcellular Locations	Cell junction Cell membrane Multi-pass membrane protein postsynaptic cell membrane synapse
Swiss Prot	P36544
克隆类型	Polyclonal Antibody
背景资料	The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.